be responsible for表示“对……负责任”，它的主语不一定是人，这种用法在美式英语中较常见。
The cold weather is responsible for his absence.
the person responsible表示“负责人”。
I want to see the person responsible.
The writer of a letter is responsible that it will be understood by its recipient.
一般来说，be responsible to后跟人，指“对某人负责”，而be responsible for后跟物，指“对某事负责”。
Who’s responsible for the terrible mess?
As a boy, i know, i was responsible to help her.
We all think of her as a responsible teacher.
You are supposed to be responsible for them.
She holds a very responsible position in the firm.
At 18, he was ill-equipped for such a responsible job.
Our teacher is a very responsible person.
She is a responsible secretary.
He holds a very responsible position in the firm.
It’s a terribly responsible job.
Since you are responsible,I thought you should know what’s happening.
It was good to feel responsible and liked.
He is responsible in morals and in law.
The children are responsible for cleaning their own rooms.
He is responsible to me for it.
I hold you personally responsible for all this.
Our duty is to hold ourselves responsible to the people.
He was held responsible for the accident.